pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols.
نویسندگان
چکیده
Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 26 شماره
صفحات -
تاریخ انتشار 2013